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To achieve therapeutic levels, high doses of GSH must be administered because it has a short half-life in blood plasma

Diarrhoea, faecal excretion and translocation of Salmonella Glutathione depletion increased relative faecal wet weight in non-infected animals whereas cystine had no effect (Figure 2A)

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Acute effects can be dose/serum concentration-related or idiosyncratic

Mechanistic and kinetic details of catalysis of thiol-disulfide exchange by glutaredoxins and potential mechanisms of regulation